St3gal2 Gene Summary [Mouse]
Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide. Acts upstream of or within protein glycosylation. Predicted to be located in Golgi membrane. Predicted to be active in membrane. Is expressed in several structures, including exocrine gland; genitourinary system; hemolymphoid system gland; intestine; and liver. Orthologous to human ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | St3gal2 |
| Official Name | ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [Source:MGI Symbol;Acc:MGI:99427] |
| Ensembl ID | ENSMUSG00000031749 |
| Bio databases IDs | |
| Aliases | ST3 beta-galactoside alpha-2,3-sialyltransferase 2 |
| Synonyms | Gal-NAc6S, Sialyltransferase 5, SIAT4B, Siat5, ST3 beta-galactoside alpha-2,3-sialyltransferase 2, ST3GalA.2, ST3GALII, ST3 β-galactoside α-2,3-sialyltransferase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse St3gal2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- sialyltransferase
- protein homodimerization
- enzyme
- monosialoganglioside sialyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
regulates
- lipid
- ganglioside GT1
- glycoprotein
- glycosphingolipid
- oligosaccharide
- keratan sulfate
- O-glycan
- glycolipid
role in cell
- proliferation
- quantity
- growth
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- Golgi membrane
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse St3gal2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- globoside biosynthetic process via lactosylceramide
- viral protein processing
- ganglioside biosynthetic process via lactosylceramide
- glycoprotein biosynthetic process
- protein glycosylation
- glycolipid biosynthetic process
- oligosaccharide biosynthetic process
- keratan sulfate biosynthetic process
- O-glycan processing
- glycosphingolipid biosynthetic process
- lipid glycosylation
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- membrane
- Golgi membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- monosialoganglioside sialyltransferase activity
- sialyltransferase activity
- beta-galactoside (CMP) alpha-2,3-sialyltransferase activity