RNF111 Gene Summary [Human]
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | RNF111 |
| Official Name | ring finger protein 111 [Source:HGNC Symbol;Acc:HGNC:17384] |
| Ensembl ID | ENSG00000157450 |
| Bio databases IDs | |
| Aliases | ring finger protein 111 |
| Synonyms | ARK, ARKADIA, hRNF111, ring finger 111, ring finger protein 111 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF111 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- SUMO interaction motif
- ubiquitin protein ligase activity
- nuclear localization sequence
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- E3 ubiquitin-protein ligase Arkadia N-terminus
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the RNF111 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- colorectal neoplasia
- gastrointestinal neoplasia
- colorectal cancer
- colorectal neoplasm
- schizophrenia
- atopic dermatitis
- opioid dependence
role in cell
- growth
- binding in
- differentiation
- accumulation in
- ubiquitination in
- degradation in
- signaling in
- recruitment in
- nucleotide excision repair in
- polysumoylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF111 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- positive regulation of protein ubiquitination
- pattern specification process
- global genome nucleotide-excision repair
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- SMAD binding
- metal ion binding
- SUMO polymer binding