RB1CC1 Gene Summary [Human]
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Details
| Type | Protein Coding |
| Official Symbol | RB1CC1 |
| Official Name | RB1 inducible coiled-coil 1 [Source:HGNC Symbol;Acc:HGNC:15574] |
| Ensembl ID | ENSG00000023287 |
| Bio databases IDs | |
| Aliases | RB1 inducible coiled-coil 1, 200 kDa FAK family kinase-interacting protein, phosphatase 1, regulatory subunit 131 |
| Synonyms | 2900055E04Rik, 5930404L04Rik, ATG17, CC1, Coiled-Coil-Forming Protein 1, FIP200, KIAA0203, LaXp180, PPP1R131, RB1-inducible coiled-coil 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RB1CC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Autophagy-related protein 11
- chromosome segregation protein SMC, primarily archaeal type
- polo kinase kinase
- exonuclease SbcC
- protein kinase binding
- protein binding activity, bridging
- helix-rich Mycoplasma protein
- coiled-coil domain
- SWI5-dependent HO expression protein 3
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Domain of unknown function (DUF4659)
- Alpha helical coiled-coil rod protein (HCR)
- Domain of unknown function (DUF4686)
- RecF/RecN/SMC N terminal domain
- Ubl1_cv_Nsp3_N-like
- Family with sequence similarity 184, A and B
- Outer membrane protein (OmpH-like)
- Apolipoprotein A1/A4/E domain
- Septation ring formation regulator, EzrA
Pathways
Biological processes and signaling networks where the RB1CC1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- neoplasia
- edema
- non-insulin-dependent diabetes mellitus
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- glioblastoma
- breast cancer
- familial breast cancer
- schizophrenia
role in cell
- expression in
- growth
- autophagy by
- apoptosis
- proliferation
- phosphorylation in
- cell viability
- quantity
- binding in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- lysosome
- cytosol
- endoplasmic reticulum membrane
- nuclear envelope
- autophagic vacuoles
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RB1CC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- extrinsic apoptotic signaling pathway
- mitochondrion degradation
- autophagic vacuole assembly
- heart development
- positive regulation of autophagy
- piecemeal microautophagy of nucleus
- ribophagy
- positive regulation of cell size
- liver development
- autophagy
- positive regulation of JNK cascade
- positive regulation of protein phosphorylation
- peroxisome degradation
- negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- cytosol
- autophagic vacuole membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- binding, bridging