CBX4 Gene Summary [Human]
Enables SUMO binding activity; SUMO ligase activity; and enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CBX4 |
| Official Name | chromobox 4 [Source:HGNC Symbol;Acc:HGNC:1554] |
| Ensembl ID | ENSG00000141582 |
| Bio databases IDs | |
| Aliases | chromobox 4, NS5ATP1-binding protein 16, Pc class 2 homolog (Drosophila) |
| Synonyms | chromobox 4, Hpc2, MPc2, NBP16, PC2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CBX4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO ligase
- Chromatin organization modifier domain
- CtBP binding domain
- transcription regulator
- SUMO transferase activity
- SUMO interaction motif
- nucleic acid binding
- C-box domain
- transcription co-repressor
- phosphoprotein binding
- enzyme binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- single-stranded RNA binding
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- double-stranded DNA binding
- Chromo (CHRromatin organization MOdifier) domain
Pathways
Biological processes and signaling networks where the CBX4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- non-insulin-dependent diabetes mellitus
- breast adenocarcinoma
- cervical cancer
- T-cell non-Hodgkin disease
- hypoplasia
- peripheral T-cell lymphoma
- mature T-cell neoplasia
- high-grade cervical neoplasia
role in cell
- expression in
- apoptosis
- activation in
- growth
- degradation in
- reactivation in
- morphology
- sumoylation in
- dexamethasone sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- polycomb group domain
- perichromatin region
- Mitochondria
- nuclear foci
- interchromatin space
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CBX4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- protein sumoylation
- negative regulation of apoptotic process
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- PRC1 complex
- nuclear body
- nuclear speck
- PcG protein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- SUMO binding
- protein binding
- transcription corepressor activity
- methylated histone residue binding
- single-stranded RNA binding
- transcription regulatory region sequence-specific DNA binding
- phosphoprotein binding
- chromatin binding
- enzyme binding
- SUMO ligase activity