TSC22D3
TSC22D3 Gene Summary
This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | TSC22D3 |
| Official Name | TSC22 domain family member 3 [Source:HGNC Symbol;Acc:HGNC:3051] |
| Ensembl ID | ENSG00000157514 |
| Bio databases IDs | |
| Aliases | TSC22 domain family member 3, glucocorticoid-induced leucine zipper |
| Synonyms | DIP,Dsip1,DSIPI,GILZ,GILZ1,Glucocorticoid-induced leucine zipper,LEUCINE ZIPPER,Tilz3,TSC22 domain family member 3,TSC22 domain family, member 3,TSC-22R |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TSC box
- transcription regulator
- PXsP motif
- RXXsL motif
- TSC-22/dip/bun family
- leucine zipper domain
- ZIP_TSC22D-like
- protein binding
- proline rich domain
- Serine Proline motif
Pathways
Biological processes and signaling networks where the TSC22D3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SCNN1B
- HRAS
- HOXB8
- ERG
- PLEKHF2
- ENDOV
- MDM2
- NFkB (complex)
- TSC22D1
- PABPC4
disease
- Huntington disease
- Alzheimer disease
- azoospermia
- hyperplasia
- hepatic steatosis
- lipopolysaccharide induced acute lung injury
- dysplasia
- diabetic nephropathy
- autoimmune disease
- sertoli cell only syndrome
regulated by
- lipopolysaccharide
- dexamethasone
- IL1B
- estrogen receptor
- beta-estradiol
- F2
- TNF
- chloropromazine
- carrageenan
- Immunoglobulin
regulates
- D-glucose
- ERK
- CASP3
- BCL2
- AKT
- TP53
- IL10
- p38 MAPK
- LEP
- IFNG
role in cell
- cell death
- expression in
- apoptosis
- activation in
- accumulation in
- survival
- differentiation
- proliferation
- production in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TSC22D3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- response to osmotic stress
- negative regulation of activation-induced cell death of T cells
- regulation of transcription from RNA polymerase II promoter
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytosol
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding