MX1 Gene Summary [Human]
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | MX1 |
| Official Name | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] |
| Ensembl ID | ENSG00000157601 |
| Bio databases IDs | |
| Aliases | MX dynamin like GTPase 1, interferon-inducible protein p78 |
| Synonyms | IFI78, IFI-78K, lncMX1-215, MX, MxA, Mxa-1, MX dynamin-like GTPase 1, MYX1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dynamin GTPase effector domain
- GTP binding
- GTP binding domain
- Dynamin central region
- oligomerization domain
- GTPase
- leucine zipper domain
- enzyme
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- Dynamin family
Pathways
Biological processes and signaling networks where the MX1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- metastasis
- Wiskott-Aldrich syndrome
- COVID-19
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- systemic lupus erythematosus
- psoriasis
- dermatomyositis
role in cell
- apoptosis
- proliferation
- cell viability
- expression in
- cell death
- motility
- growth
- growth in
- replication in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- perinuclear region
- Nucleus
- cytosol
- nuclear pores
- nuclear envelope
- smooth endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- innate immune response
- response to type I interferon
- apoptotic process
- defense response to virus
- defense response
- response to virus
- negative regulation of viral genome replication
- interleukin-27-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- nuclear membrane
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- GTPase activity
- microtubule binding