SIAH2 Gene Summary [Human]
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SIAH2 |
| Official Name | siah E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:10858] |
| Ensembl ID | ENSG00000181788 |
| Bio databases IDs | |
| Aliases | siah E3 ubiquitin protein ligase 2 |
| Synonyms | hSiah2, siah E3 ubiquitin protein ligase 2, Sinh2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIAH2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acid-D-amino acid ligase
- transcription regulator
- ubiquitin protein ligase activity
- transcription co-repressor
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- Seven in absentia protein family
- enzyme binding
- cysteine-histidine rich domain
- protein binding
- substrate binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostatic neoplasia
- renal cell cancer
- breast carcinoma
- Waldenström macroglobulinemia
- renal cell carcinoma
- limited systemic sclerosis
role in cell
- growth
- quantity
- cell viability
- formation
- expression in
- activation in
- G2/M phase
- apoptosis
- differentiation
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- vesicles
- cytosol
- nucleoplasm
- early endosomes
- synaptic-like microvesicles
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIAH2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- regulation of circadian rhythm
- ubiquitin-dependent protein catabolic process
- negative regulation of canonical Wnt receptor signaling pathway
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of transcription, DNA-dependent
- rhythmic process
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of apoptotic process
- apoptotic process
- canonical Wnt receptor signaling pathway
- negative regulation of extrinsic apoptotic signaling pathway
- regulation of protein ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- neuronal cell body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ubiquitin conjugating enzyme binding
- zinc ion binding
- protein binding
- transcription corepressor activity