ZFAND2B Gene Summary [Human]

This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Details

Type
Protein Coding
Official Symbol
ZFAND2B
Official Name
zinc finger AN1-type containing 2B [Source:HGNC Symbol;Acc:HGNC:25206]
Ensembl ID
ENSG00000158552
Bio databases IDs NCBI: 130617 Ensembl: ENSG00000158552
Aliases zinc finger AN1-type containing 2B, arsenite inducible RNA associated protein-like
Synonyms 1110060O18Rik, AIRAPL, RGD1306260, zinc finger AN1-type containing 2B, zinc finger, AN1 type domain 2B
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFAND2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Ubiquitin-interacting motif
  • Ubiquitin interaction motif
  • ubiquitin binding
  • protein binding
  • AN1-like Zinc finger

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • schizophrenia
regulated by
regulates
  • proteasome

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cellular membrane
  • Endoplasmic Reticulum

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ZFAND2B gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • SRP-dependent cotranslational protein targeting to membrane, translocation
  • proteasomal ubiquitin-dependent protein catabolic process
  • protein targeting to ER
  • regulation of insulin-like growth factor receptor signaling pathway

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • cytoplasm
  • membrane
  • proteasome complex
  • endoplasmic reticulum

Molecular Function

What the gene product does at the molecular level
  • zinc ion binding
  • protein binding
  • ubiquitin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.