Zfand2b Gene Summary [Mouse]
Enables K48-linked polyubiquitin modification-dependent protein binding activity and ubiquitin binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein targeting to ER; and regulation of insulin-like growth factor receptor signaling pathway. Located in endoplasmic reticulum and membrane. Part of proteasome complex. Orthologous to human ZFAND2B (zinc finger AN1-type containing 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfand2b |
| Official Name | zinc finger, AN1 type domain 2B [Source:MGI Symbol;Acc:MGI:1916068] |
| Ensembl ID | ENSMUSG00000026197 |
| Bio databases IDs | |
| Aliases | zinc finger, AN1 type domain 2B |
| Synonyms | 1110060O18Rik, AIRAPL, RGD1306260, zinc finger AN1-type containing 2B, zinc finger, AN1 type domain 2B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfand2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-interacting motif
- Ubiquitin interaction motif
- ubiquitin binding
- protein binding
- AN1-like Zinc finger
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfand2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane, translocation
- proteasomal ubiquitin-dependent protein catabolic process
- protein targeting to ER
- regulation of insulin-like growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- membrane
- proteasome complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ubiquitin binding