GPAT4 Gene Summary [Human]
Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
Details
| Type | Processed Transcript |
| Official Symbol | GPAT4 |
| Official Name | glycerol-3-phosphate acyltransferase 4 [Source:HGNC Symbol;Acc:HGNC:20880] |
| Ensembl ID | ENSG00000158669 |
| Bio databases IDs | |
| Aliases | glycerol-3-phosphate acyltransferase 4, lysophosphatidic acid acyltransferase, zeta |
| Synonyms | 1-AGPAT 6, AGPAT6, glycerol-3-phosphate acyltransferase 4, LOC55933, LPAATZ, LPAAT-zeta, LPAAT-ζ, RGD1310520, TSARG7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPAT4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 1-acylglycerol-3-phosphate O-acyltransferase
- glycerol-3-phosphate O-acyltransferase
- enzyme
- protein binding
- Acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- breast cancer
role in cell
- expression in
- quantity
- accumulation in
- size
- lipotoxicity in
- signaling in
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- lipid droplets
- endoplasmic reticulum membrane
- inner nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPAT4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- regulation of multicellular organism growth
- glandular epithelial cell maturation
- triglyceride biosynthetic process
- lipid biosynthetic process
- lactation
- CDP-diacylglycerol biosynthetic process
- phosphatidylcholine biosynthetic process
- fatty acid metabolic process
- diacylglycerol metabolic process
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- glycerol-3-phosphate O-acyltransferase activity