CTDSP1 Gene Summary [Human]
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Processed Transcript |
| Official Symbol | CTDSP1 |
| Official Name | CTD small phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:21614] |
| Ensembl ID | ENSG00000144579 |
| Bio databases IDs | |
| Aliases | CTD small phosphatase 1, nuclear LIM interactor-interacting factor, small CTD phosphatase 1 |
| Synonyms | CTD small phosphatase 1, GIP, NIF3, NLI-IF, SCP1, Tsap1, Tsip1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CTDSP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTD phosphatase
- FCP1-like phosphatase, phosphatase domain
- phosphatase
- protein binding
- phosphatase domain
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- chronic lymphocytic leukemia
- gastric epithelial cancer
role in cell
- phosphorylation in
- expression in
- proliferation
- degradation in
- differentiation
- migration
- invasion by
- dephosphorylation in
- ubiquitination in
- neurogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CTDSP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein phosphorylation
- protein dephosphorylation
- negative regulation of neuron differentiation
- negative regulation of G1/S transition of mitotic cell cycle
- negative regulation of neurogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- CTD phosphatase activity
- myosin phosphatase activity