THEM4 Gene Summary [Human]
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | THEM4 |
| Official Name | thioesterase superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:17947] |
| Ensembl ID | ENSG00000159445 |
| Bio databases IDs | |
| Aliases | thioesterase superfamily member 4, C-terminal modulator protein |
| Synonyms | 2700077M13RIK, 4921507I02Rik, CTMP, RGD1304723, thioesterase superfamily member 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THEM4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thioesterase superfamily
- hot_dog
- enzyme
- protein binding
- acyl-CoA hydrolase
Pathways
Biological processes and signaling networks where the THEM4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- androgenic alopecia
- breast cancer
- organismal death
role in cell
- expression in
- accumulation in
- phosphorylation in
- proliferation
- morphology
- growth
- tumorigenicity
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Mitochondria
- cytosol
- membrane ruffles
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THEM4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid metabolic process
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial matrix
- mitochondrion
- cytosol
- ruffle membrane
- mitochondrial inner membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- long-chain acyl-CoA hydrolase activity