RPN2 Gene Summary [Human]
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | RPN2 |
| Official Name | ribophorin II [Source:HGNC Symbol;Acc:HGNC:10382] |
| Ensembl ID | ENSG00000118705 |
| Bio databases IDs | |
| Aliases | ribophorin II, oligosaccharyltransferase complex subunit (non-catalytic) |
| Synonyms | 1300012C06Rik, AV261018, RIBIIR, ribophorin II, RPN-II, SWP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dolichyl-diphosphooligosaccharide-protein glycotransferase
- ribosome binding
- Oligosaccharyltransferase subunit Ribophorin II
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- adenoma formation
- invasive breast cancer
- cutaneous melanoma
- cutaneous melanoma cancer
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- metastasis
role in cell
- expression in
- proliferation
- glycolysis in
- survival
- cisplatin sensitivity
- degradation in
- reprogramming in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- inner nuclear membrane
- nuclear bodies
- autophagic vacuoles
- rough endoplasmatic reticulum
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- oligosaccharyltransferase complex
- nuclear body
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- dolichyl-diphosphooligosaccharide-protein glycotransferase activity
- protein binding