PMF1 Gene Summary [Human]
Enables leucine zipper domain binding activity and transcription coactivator activity. Involved in chromosome segregation. Located in Golgi apparatus; kinetochore; and nucleoplasm. Part of MIS12/MIND type complex. Implicated in bladder carcinoma and urinary bladder cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PMF1 |
| Official Name | polyamine modulated factor 1 [Source:HGNC Symbol;Acc:HGNC:9112] |
| Ensembl ID | ENSG00000160783 |
| Bio databases IDs | |
| Aliases | polyamine modulated factor 1 |
| Synonyms | 2600009M07Rik, LOC686408, polyamine-modulated factor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PMF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- LRR-domain binding
- coiled-coil domain
- leucine zipper domain
- protein binding
- Nnf1
Pathways
Biological processes and signaling networks where the PMF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- COVID-19
- ischemic stroke
- Waldenström macroglobulinemia
- small vessel disease stroke
- myeloproliferative disorder
- renal clear cell adenocarcinoma
- renal clear cell cancer
- stroke
- systemic juvenile idiopathic arthritis
role in cell
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Golgi Apparatus
- cytosol
- nucleoplasm
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PMF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of transcription, DNA-dependent
- attachment of spindle microtubules to kinetochore
- transcription from RNA polymerase II promoter
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- intracellular membrane-bounded organelle
- spindle pole
- cytosol
- Golgi apparatus
- kinetochore
- MIS12/MIND type complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- leucine zipper domain binding