Pmf1 Gene Summary [Mouse]
Predicted to enable leucine zipper domain binding activity and transcription coactivator activity. Predicted to be involved in chromosome segregation. Predicted to be located in Golgi apparatus; kinetochore; and nucleoplasm. Predicted to be part of MIS12/MIND type complex. Is expressed in several structures, including central nervous system; extraembryonic component; placenta; retina; and thymus. Human ortholog(s) of this gene implicated in bladder carcinoma and urinary bladder cancer. Orthologous to several human genes including PMF1 (polyamine modulated factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pmf1 |
| Official Name | polyamine-modulated factor 1 [Source:MGI Symbol;Acc:MGI:1914287] |
| Ensembl ID | ENSMUSG00000028066 |
| Bio databases IDs | |
| Aliases | polyamine-modulated factor 1 |
| Synonyms | 2600009M07Rik, LOC686408, polyamine-modulated factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pmf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- LRR-domain binding
- coiled-coil domain
- leucine zipper domain
- protein binding
- Nnf1
Pathways
Biological processes and signaling networks where the Pmf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- COVID-19
- ischemic stroke
- Waldenström macroglobulinemia
- small vessel disease stroke
- myeloproliferative disorder
- renal clear cell adenocarcinoma
- renal clear cell cancer
- stroke
- systemic juvenile idiopathic arthritis
role in cell
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Golgi Apparatus
- cytosol
- nucleoplasm
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pmf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of transcription, DNA-dependent
- attachment of spindle microtubules to kinetochore
- transcription from RNA polymerase II promoter
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- intracellular membrane-bounded organelle
- spindle pole
- cytosol
- Golgi apparatus
- kinetochore
- MIS12/MIND type complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- leucine zipper domain binding