PTGER1 Gene Summary [Human]
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PTGER1 |
| Official Name | prostaglandin E receptor 1 [Source:HGNC Symbol;Acc:HGNC:9593] |
| Ensembl ID | ENSG00000160951 |
| Bio databases IDs | |
| Aliases | prostaglandin E receptor 1 |
| Synonyms | EP1, prostaglandin E receptor 1, prostaglandin E receptor 1 (subtype EP1), Ptgerep1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTGER1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- prostaglandin E receptor
- G-protein-coupled receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the PTGER1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- experimental autoimmune encephalomyelitis
- pulmonary hypertension
- glaucoma
- ocular hypertension
- pain
- neoplasia
- pulmonary hypertensive arterial disease
- open-angle glaucoma
- prostate cancer
role in cell
- expression in
- degradation in
- apoptosis
- activation
- differentiation
- migration
- colonization
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- inner nuclear membrane
- outer nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTGER1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- adenylate cyclase-activating dopamine receptor signaling pathway
- G-protein coupled receptor signaling pathway
- response to lipopolysaccharide
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- D1 dopamine receptor binding
- prostaglandin E receptor activity