FBXL13 Gene Summary [Human]
Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | FBXL13 |
| Official Name | F-box and leucine rich repeat protein 13 [Source:HGNC Symbol;Acc:HGNC:21658] |
| Ensembl ID | ENSG00000161040 |
| Bio databases IDs | |
| Aliases | F-box and leucine rich repeat protein 13, cilia and flagella associated protein 169 |
| Synonyms | 4921539K22RIK, CFAP169, DRC6, Fbl13, F-box and leucine-rich repeat protein 13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXL13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- protein phosphatase 1 regulatory subunit 42
- F-box domain superfamily
- Leucine-rich repeat - CC (cysteine-containing) subfamily
- F-box-like
- enzyme
- protein binding
- DD_R_PKA_DPY30-like
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- autoimmune disease
- age-related hearing loss
- hearing loss
- breast carcinoma
- Alzheimer disease
- diverticular disease
- colorectal adenoma
- colorectal adenoma formation
regulated by
- PPRC1
- carbonyl cyanide m-chlorophenyl hydrazone
regulates
- gamma tubulin (family)
- CEP192
role in cell
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXL13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- motile cilium
- cytosol
- SCF ubiquitin ligase complex