Fbxl13 Gene Summary [Mouse]
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in centrosome; cytoplasm; and motile cilium. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in brain; lung; and reproductive system. Orthologous to human FBXL13 (F-box and leucine rich repeat protein 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxl13 |
| Official Name | F-box and leucine-rich repeat protein 13 [Source:MGI Symbol;Acc:MGI:2443416] |
| Ensembl ID | ENSMUSG00000048520 |
| Bio databases IDs | |
| Aliases | F-box and leucine-rich repeat protein 13 |
| Synonyms | 4921539K22RIK, CFAP169, DRC6, Fbl13, F-box and leucine-rich repeat protein 13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxl13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- protein phosphatase 1 regulatory subunit 42
- F-box domain superfamily
- Leucine-rich repeat - CC (cysteine-containing) subfamily
- F-box-like
- enzyme
- protein binding
- DD_R_PKA_DPY30-like
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- autoimmune disease
- age-related hearing loss
- hearing loss
- breast carcinoma
- Alzheimer disease
- diverticular disease
- colorectal adenoma
- colorectal adenoma formation
regulated by
- PPRC1
- carbonyl cyanide m-chlorophenyl hydrazone
regulates
- gamma tubulin (family)
- CEP192
role in cell
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxl13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- motile cilium
- cytosol
- SCF ubiquitin ligase complex