ABCB1
ABCB1 Gene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Details
| Type | Protein Coding |
| Official Symbol | ABCB1 |
| Official Name | ATP binding cassette subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:40] |
| Ensembl ID | ENSG00000085563 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily B member 1, multidrug resistance protein 1, P-glycoprotein |
| Synonyms | ABC20,Abcb1b,ATP binding cassette subfamily B member 1,ATP-binding cassette, sub-family B member 1B,CD243,CLCS,ENPAT,GP170,mdr,MDR1,Mdr1b,p-170,P-GLYCOPROTEIN,P-GP,PGY1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
- carboxylic acid transporter
- walker type B motif
- efflux permease
- phospholipid transporter
- ATP binding
- Conjugate Transporter-2 (CT2) Family protein
- nitrate transport ATP-binding subunits C and D
- heme ABC exporter, ATP-binding protein CcmA
- nucleotide-binding domain
- energy-coupling factor transporter ATPase
- xenobiotic-transporting ATPase
- nickel import ATP-binding protein NikE
- nucleotide binding fold domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- ATPase activity, coupled to transmembrane movement of substances
- ubiquitin protein ligase binding
- lipid A export permease/ATP-binding protein MsbA
- linker domain
- sphingolipid-translocating ATPase
- protein binding
- urea ABC transporter, ATP-binding protein UrtE
- ABC transporter transmembrane region
- lipid transporter
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- phosphatidylcholine transporter
- xenobiotic transporter
- transmembrane domain
- ABC transporter
- ABC transporter, permease/ATP-binding protein
- transporter
Pathways
Biological processes and signaling networks where the ABCB1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- sertraline
- IGF2BP2
- apixaban
- SAAL1
- NR1I2
- RXRA
- SP1
- SP3
- IFIT5
- KRAS
disease
- metastatic non-small cell lung cancer
- squamous cell lung cancer
- metastatic breast cancer
- major depression
- rheumatoid arthritis
- acquired immunodeficiency syndrome
- myalgia
- COVID-19
- systemic lupus erythematosus
- lung cancer
regulated by
- ritonavir
- ouabain
- digoxin
- KYNU
- HIF1A
- bosutinib
- ABCB1
- SMARCB1
- progesterone
- sulforhodamine methanethiosulfonate
regulates
- IFNG
- corticosterone
- TTK
- P glycoprotein
- ABCB1
- BAX
- glucosylceramide
- vinblastine
- C6-NBD-glucosylceramide
- daunorubicin
role in cell
- expression in
- invasion by
- cell death
- proliferation
- migration
- survival
- apoptosis
- cell viability
- growth
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- pH resistant lipid raft fraction
- cholesterol-rich microdomain
- Cytoplasm
- cell surface
- membrane surface
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- plasma membrane extracellular face
- apical membrane
- Golgi membrane
- brush border
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ABCB1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of response to osmotic stress
- transmembrane transport
- G2/M transition of mitotic cell cycle
- phospholipid translocation
- stem cell proliferation
- xenobiotic metabolic process
- regulation of chloride transport
- transepithelial transport
- terpenoid transport
- response to xenobiotic stimulus
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- plasma membrane
- apical plasma membrane
- cell surface
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATPase activity
- xenobiotic transporter activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- protein binding
- ubiquitin protein ligase binding
- efflux transmembrane transporter activity
- transmembrane transporter activity
- xenobiotic-transporting ATPase activity
- carboxylic acid transmembrane transporter activity