TAF6L Gene Summary [Human]
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TAF6L |
| Official Name | TATA-box binding protein associated factor 6 like [Source:HGNC Symbol;Acc:HGNC:17305] |
| Ensembl ID | ENSG00000162227 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 6 like |
| Synonyms | 2810417N14RIK, C530024J06Rik, PAF65A, TATA-box binding protein associated factor 6 like |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAF6L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- transcription regulator
- transcription co-activator
- TATA box binding protein associated factor (TAF)
- C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
- protein binding
- TATA box binding protein associated factor
- DNA binding
Pathways
Biological processes and signaling networks where the TAF6L gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAF6L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase II transcriptional preinitiation complex assembly
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of DNA repair
- regulation of RNA splicing
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- transcription factor TFIID complex
- SLIK (SAGA-like) complex
- histone deacetylase complex
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity