MBIP Gene Summary [Human]
Enables identical protein binding activity and protein kinase inhibitor activity. Involved in histone H3 acetylation; positive regulation of JNK cascade; and positive regulation of gene expression. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MBIP |
| Official Name | MAP3K12 binding inhibitory protein 1 [Source:HGNC Symbol;Acc:HGNC:20427] |
| Ensembl ID | ENSG00000151332 |
| Bio databases IDs | |
| Aliases | MAP3K12 binding inhibitory protein 1 |
| Synonyms | 4933408E06Rik, MAP3K12 binding inhibitory protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MBIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase inhibitor activity
- leucine zipper domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
regulated by
- MYC
- dexamethasone
- filgrastim
role in cell
- phosphorylation in
- expression in
- proliferation
- migration
- invasion by
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MBIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell division
- positive regulation of gene expression
- positive regulation of JNK cascade
- regulation of embryonic development
- regulation of tubulin deacetylation
- regulation of transcription, DNA-dependent
- regulation of cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- mitotic spindle
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein kinase inhibitor activity