TAF10 Gene Summary [Human]
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TAF10 |
| Official Name | TATA-box binding protein associated factor 10 [Source:HGNC Symbol;Acc:HGNC:11543] |
| Ensembl ID | ENSG00000166337 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 10 |
| Synonyms | TAF2A, TAF2H, TAFII30, TAFII30 alpha, TAFII30 beta, TAFII30 α, TAFII30 β, TATA-box binding protein associated factor 10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAF10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- transcription regulator
- histone acetyltransferase
- methylation site
- enzyme binding
- chromatin binding
- protein binding
- general RNA polymerase II transcription factor
- estrogen receptor binding
- identical protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the TAF10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- psoriasis
role in cell
- expression in
- differentiation
- binding in
- apoptosis
- morphology
- G2 phase
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- Cytoplasm
- perinuclear region
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAF10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- multicellular organism growth
- limb development
- positive regulation of transcription initiation from RNA polymerase II promoter
- regulation of DNA repair
- transcription from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
- transcription initiation, DNA-dependent
- embryonic placenta development
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription, DNA-dependent
- somitogenesis
- hepatocyte differentiation
- regulation of RNA splicing
- G1/S transition of mitotic cell cycle
- apoptotic process
- lateral mesodermal cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- perinuclear region of cytoplasm
- transcription factor TFTC complex
- cytoplasm
- SAGA complex
- nucleoplasm
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- histone acetyltransferase activity
- DNA binding
- identical protein binding
- protein binding
- general RNA polymerase II transcription factor activity
- estrogen receptor binding
- enzyme binding