TAF5L Gene Summary [Human]
The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TAF5L |
| Official Name | TATA-box binding protein associated factor 5 like [Source:HGNC Symbol;Acc:HGNC:17304] |
| Ensembl ID | ENSG00000135801 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 5 like, PCAF associated factor 65 beta |
| Synonyms | 1110005N04Rik, PAF65B, Taf5l1, TATA-box binding protein associated factor 5 like, TATA-box binding protein associated factor 5 like 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAF5L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- TAF5 N-terminal domain 2
- transcription regulator
- transcription co-activator
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the TAF5L gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic ribonucleoprotein granule
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAF5L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of DNA repair
- regulation of RNA splicing
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- transcription factor TFTC complex
- nuclear speck
- SAGA complex
- histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity