FCGR3B Gene Summary [Human]
The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | FCGR3B |
| Official Name | Fc fragment of IgG receptor IIIb [Source:HGNC Symbol;Acc:HGNC:3620] |
| Ensembl ID | ENSG00000162747 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgG receptor IIIb, Fc gamma receptor IIIb |
| Synonyms | Antigen CD16-B, CD16, CD16A, CD16b, CD16-I, FCG3, Fc gamma receptor IIIb, FC gamma RIIIB, Fc-gamma RIII-beta, FCGR3, FCGR3A, FCR-10, FCRIII, FcRIIIb, Fc γ receptor IIIb, FC γ RIIIB, Fc-γ RIII-β |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCGR3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- lipid binding
- binding protein
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- transmembrane receptor
- glycosylphosphatidylinositol anchor sequence
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the FCGR3B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- dermatomyositis
- relapsing multiple sclerosis
- pure red cell aplasia
- pneumonitis
- COVID-19
- immunodeficiency
- cytomegalovirus infection
- schizophrenia
- chronic inflammatory demyelinating polyradiculoneuropathy
role in cell
- expression in
- phagocytosis by
- recruitment
- binding
- accumulation
- degranulation
- cytotoxicity
- trogocytosis
- trogocytosis by
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- secretory granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCGR3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- antibody-dependent cellular cytotoxicity
- Fc-gamma receptor signaling pathway
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- extracellular vesicular exosome
- external side of plasma membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- IgG receptor activity
- GPI anchor binding
- IgG binding