FCGR3A Gene Summary [Human]
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | FCGR3A |
| Official Name | Fc fragment of IgG receptor IIIa [Source:HGNC Symbol;Acc:HGNC:3619] |
| Ensembl ID | ENSG00000203747 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgG receptor IIIa, Fc gamma receptor IIIa |
| Synonyms | Antigen CD16-A, CD16, CD16A, CD16-II, FCG3, Fc Gamma R3, Fc gamma receptor IIIa, FC gamma RIII, FC gamma RIIIA, FC gamma RIIIA alpha, Fc-gamma RIII-alpha, FCGR3, FCGRIII, FcGRIIIA, FCR-10, FCRIII, FCRIIIA, Fc γ R3, Fc γ receptor IIIa, FC γ RIII, FC γ RIIIA, FC γ RIIIA α, Fc-γ RIII-α, IGFR3, IMD20 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCGR3A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- immunoglobulin domain
- ectodomain
- transmembrane domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- low affinity IgG receptor
- protein binding
- transmembrane receptor
- glycosylphosphatidylinositol anchor sequence
Pathways
Biological processes and signaling networks where the FCGR3A gene in human plays a role, providing insight into its function and relevance in health or disease.
- Dendritic Cell Maturation
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- IL-12 Signaling and Production in Macrophages
- Natural Killer Cell Signaling
- Parkinson's Signaling Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- HIV infection
- bladder cancer
- cancer
- breast cancer
- leukemia
- prostate cancer
- single system Langerhans cell histiocytosis
- metastatic bladder cancer
- ovarian cancer
role in cell
- production in
- apoptosis
- expression in
- binding
- binding in
- activation in
- cytotoxicity
- cell rolling
- activation
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCGR3A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Fc-gamma receptor signaling pathway
- natural killer cell degranulation
- cell surface receptor signaling pathway
- natural killer cell mediated cytotoxicity
- macrophage activation
- protein kinase B signaling cascade
- immune response
- antibody-dependent cellular cytotoxicity
- positive regulation of natural killer cell proliferation
- positive regulation of tumor necrosis factor production
- natural killer cell activation
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- Fc-gamma receptor III complex
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- IgG receptor activity
- low affinity IgG receptor activity
- IgG binding