BPNT1 Gene Summary [Human]
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BPNT1 |
| Official Name | 3'(2'), 5'-bisphosphate nucleotidase 1 [Source:HGNC Symbol;Acc:HGNC:1096] |
| Ensembl ID | ENSG00000162813 |
| Bio databases IDs | |
| Aliases | 3'(2'), 5'-bisphosphate nucleotidase 1 |
| Synonyms | 3'(2'), 5'-bisphosphate nucleotidase 1, BPntase, HEL20, HsPIP, PIP, Sal3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BPNT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'(2'),5'-bisphosphate nucleotidase
- inositol-1,4-bisphosphate 1-phosphatase
- phosphatase
- 3'(2'),5'-bisphosphate nucleotidase, bacterial
- Inositol monophosphatase family
- FIG
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoproteinemia
- hypoalbuminemia
- chronic lymphocytic leukemia
- anasarca
- iron deficiency anemia
- edema
role in cell
- growth
- damage
- tubulation
- abnormal morphology
- tubulation in
- fragmentation in
- aberration in
- fragmentation
- aberration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BPNT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
- phosphatidylinositol phosphorylation
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- 3'(2'),5'-bisphosphate nucleotidase activity
- metal ion binding
- inositol-1,4-bisphosphate 1-phosphatase activity