MICU2 Gene Summary [Human]
Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | MICU2 |
| Official Name | mitochondrial calcium uptake 2 [Source:HGNC Symbol;Acc:HGNC:31830] |
| Ensembl ID | ENSG00000165487 |
| Bio databases IDs | |
| Aliases | mitochondrial calcium uptake 2 |
| Synonyms | 1110008L20Rik, 4833427E09Rik, EFHA1, hMICU3, mitochondrial calcium uptake 2, RGD1309934, Smhs2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MICU2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain pair
- calcium ion binding
- EFh
- protein binding
- EFh_MICU
- calcium channel regulator
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial intermembrane space
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MICU2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- elevation of mitochondrial calcium ion concentration
- reduction of mitochondrial calcium ion concentration
- mitochondrial calcium ion homeostasis
- mitochondrial calcium ion transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- calcium channel complex
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- calcium ion binding