APOL2 Gene Summary [Human]

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
APOL2
Official Name
apolipoprotein L2 [Source:HGNC Symbol;Acc:HGNC:619]
Ensembl ID
ENSG00000128335
Bio databases IDs NCBI: 23780 Ensembl: ENSG00000128335
Aliases apolipoprotein L2, apolipoprotein L-II
Synonyms APOL3, APOL-II, apolipoprotein L2
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human APOL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein binding
  • Apolipoprotein L

Pathways

Biological processes and signaling networks where the APOL2 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • cervical cancer
  • non-insulin-dependent diabetes mellitus
  • Alzheimer disease
  • celiac disease
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human APOL2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • lipid transport
  • maternal process involved in female pregnancy
  • lipid metabolic process
  • cholesterol metabolic process
  • lipoprotein metabolic process
  • acute-phase response

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • membrane
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • lipid binding
  • high-density lipoprotein particle binding
  • receptor binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.