TRADD Gene Summary [Human]
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRADD |
| Official Name | TNFRSF1A associated via death domain [Source:HGNC Symbol;Acc:HGNC:12030] |
| Ensembl ID | ENSG00000102871 |
| Bio databases IDs | |
| Aliases | TNFRSF1A associated via death domain |
| Synonyms | 9130005N23Rik, Hs.89862, TNFRSF1A-ASSOCIATED VIA DEATH domain |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRADD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- tumor necrosis factor receptor binding
- protein binding activity, bridging
- protein domain specific binding
- protein binding
- identical protein binding
- Sh3 domain binding motif
- kinase binding
- TRAF binding domain
- binding protein
- transmembrane receptor protein tyrosine kinase adaptor protein
- Death Domain Superfamily of protein-protein interaction domains
- TRADD, N-terminal domain
Pathways
Biological processes and signaling networks where the TRADD gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Death Receptor Signaling
- Induction of Apoptosis by HIV1
- Myc Mediated Apoptosis Signaling
- NF-κB Signaling
- p38 MAPK Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- SAPK/JNK Signaling
- TNFR1 Signaling
- TWEAK Signaling
- Type I Diabetes Mellitus Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- prostatic adenocarcinoma
- unilateral ureteral obstruction
- acute inflammation
- psoriatic arthritis
- plasma cell neoplasm
- B cell cancer
- mature B-cell neoplasia
role in cell
- expression in
- production in
- migration
- accumulation in
- apoptosis
- activation in
- proliferation
- generation in
- cell viability
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear Golgi regions
- perinuclear region
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- perinuclear vesicles
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRADD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of inflammatory response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- extrinsic apoptotic signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- induction of apoptosis via death domain receptors
- I-kappaB kinase/NF-kappaB cascade
- positive regulation of NF-kappaB transcription factor activity
- tumor necrosis factor-mediated signaling pathway
- positive regulation of apoptotic process
- apoptotic process
- cellular response to tumor necrosis factor
- positive regulation of hair follicle development
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- cytosol
- death-inducing signaling complex
- receptor complex
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- tumor necrosis factor receptor binding
- transmembrane receptor protein tyrosine kinase adaptor activity
- kinase binding
- death domain binding
- binding, bridging