INHBB Gene Summary [Human]
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | INHBB |
| Official Name | inhibin subunit beta B [Source:HGNC Symbol;Acc:HGNC:6067] |
| Ensembl ID | ENSG00000163083 |
| Bio databases IDs | |
| Aliases | inhibin subunit beta B |
| Synonyms | activin AB beta polypeptide precursor, activin AB β polypeptide precursor, Activin B, activin beta B, Activin β B, Beta-B, Inhibin B, inhibin beta-B, inhibin subunit beta B, inhibin subunit β B, inhibin β-B, Inhibin β b subunit, β-B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INHBB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TGF_beta_SF
- protein homodimerization
- Transforming growth factor beta like domain
- hormone
- protein binding
- pro domain
- growth factor
- TGF-beta propeptide
- host cell surface receptor binding
Pathways
Biological processes and signaling networks where the INHBB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myelodysplastic syndrome
- non-insulin-dependent diabetes mellitus
- neoplasia
- myelodysplastic syndrome with ring sideroblasts
- post polycythemia vera myelofibrosis
- organismal death
- myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis
- epithelial cancer
- myelofibrosis
- anemia
role in cell
- apoptosis
- expression in
- proliferation
- growth
- migration
- phosphorylation in
- activation in
- invasion by
- quantity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell periphery
- perinuclear region
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INHBB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to wounding
- apoptotic signaling pathway
- fat cell differentiation
- negative regulation of insulin secretion
- cellular response to insulin stimulus
- cellular response to thyroid hormone stimulus
- activin receptor signaling pathway
- negative regulation of follicle-stimulating hormone secretion
- cellular response to calcium ion
- response to insecticide
- seminiferous tubule development
- cellular response to leptin stimulus
- cellular response to cholesterol
- positive regulation of follicle-stimulating hormone secretion
- negative regulation of hepatocyte growth factor production
- spermatogenesis
- cellular response to starvation
- defense response
- positive regulation of ovulation
- pituitary gland development
- ovarian follicle development
- oocyte development
- cellular response to cAMP
- cell differentiation
- cellular response to interleukin-1
- response to gonadotropin stimulus
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- perinuclear region of cytoplasm
- extracellular region
- cell periphery
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- protein homodimerization activity
- cytokine activity
- hormone activity
- host cell surface receptor binding