INHA Gene Summary [Human]
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]
Details
| Type | Processed Transcript |
| Official Symbol | INHA |
| Official Name | inhibin subunit alpha [Source:HGNC Symbol;Acc:HGNC:6065] |
| Ensembl ID | ENSG00000123999 |
| Bio databases IDs | |
| Aliases | inhibin subunit alpha |
| Synonyms | INHIBIN A, Inhibin Alpha, inhibin subunit alpha, inhibin subunit α, Inhibin α, Inhibin α Subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INHA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- TGF_beta_SF
- Transforming growth factor beta like domain
- hormone
- protein binding
- receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the INHA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- tumorigenesis
- sex cord stromal neoplasm
- wasting syndrome
- cachexia
- anemia
- premature ovarian failure
role in cell
- growth
- expression in
- apoptosis
- proliferation
- formation
- differentiation
- quantity
- number
- necrosis
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Plasma Membrane
- photoreceptor outer segments
- photoreceptor inner segments
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INHA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gonad development
- signal transduction
- cell-cell signaling
- negative regulation of cell cycle
- negative regulation of B cell differentiation
- cell surface receptor signaling pathway
- hemoglobin biosynthetic process
- regulation of cell proliferation
- negative regulation of phosphorylation
- ovarian follicle development
- erythrocyte differentiation
- skeletal system development
- negative regulation of macrophage differentiation
- negative regulation of follicle-stimulating hormone secretion
- positive regulation of follicle-stimulating hormone secretion
- cell differentiation
- regulation of cell cycle
- negative regulation of interferon-gamma production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- inhibin-betaglycan-ActRII complex
- neuronal cell body
- extracellular region
- inhibin A complex
- photoreceptor inner segment
- photoreceptor outer segment
- inhibin B complex
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- cytokine activity
- receptor binding
- hormone activity
- inhibin binding