THBS1 Gene Summary [Human]
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | THBS1 |
| Official Name | thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] |
| Ensembl ID | ENSG00000137801 |
| Bio databases IDs | |
| Aliases | thrombospondin 1, thrombospondin-1p180 |
| Synonyms | tbsp1, THBS, thrombospondin 1, THSP, TS-1, TSP, TSP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THBS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 domain
- CD36-binding domain
- cell-binding domain
- thrombospondin type 1 repeat
- globular domain
- heparin binding domain
- signal peptide
- low-density lipoprotein binding
- calcium binding loop
- TGFbeta binding
- thrombospondin type 3 repeat
- Thrombospondin type 2 repeat
- L-lectin like domain
- IAP binding domain
- von Willebrand factor type C domain
- thrombospondin properdin-like repeat
- laminin G domain
- Thrombospondin type 1 repeats
- phospholipid binding
- Procollagen-like segment
- thrombospondin-1 motif
- protease binding
- LamG
- oligomerization domain
- extracellular matrix binding
- extracellular matrix structural constituent
- protein binding
- Alpha3 beta1 integrin-binding domain
- fibronectin binding
- EGF-like domain
- endopeptidase inhibitor
- Thrombospondin C-terminal region
- binding protein
- laminin binding
- fibroblast growth factor binding
- stalk region
- integrin binding
- collagen binding
- protein homodimerization
- EGF domain
- Spondin-like TSP1 domain
- heparin binding
Pathways
Biological processes and signaling networks where the THBS1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- cholangiocarcinoma cancer
- bile duct cancer
- biliary tract cancer
- epithelial cancer
- pancreaticobiliary cancer
role in cell
- growth
- expression in
- phosphorylation in
- apoptosis
- cell viability
- cell death
- formation
- formation in
- proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- extracellular vesicles
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- plasma membrane extracellular face
- alpha granules
- secretory granules
- extracellular matrix
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THBS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative regulation of fibroblast growth factor receptor signaling pathway
- positive regulation of translation
- positive regulation of blood coagulation
- response to progesterone stimulus
- sprouting angiogenesis
- negative regulation of cell migration involved in sprouting angiogenesis
- positive regulation of angiogenesis
- inflammatory response
- response to glucose stimulus
- response to hypoxia
- immune response
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of macrophage activation
- apoptotic process
- positive regulation of endothelial cell apoptotic process
- positive regulation of tumor necrosis factor production
- response to testosterone stimulus
- nitric oxide-cGMP-mediated signaling pathway
- negative regulation of focal adhesion assembly
- positive regulation of transforming growth factor beta1 production
- negative regulation of cell-matrix adhesion
- cellular response to growth factor stimulus
- negative regulation of dendritic cell antigen processing and presentation
- negative regulation of plasma membrane long-chain fatty acid transport
- peptide cross-linking
- positive regulation of chemotaxis
- response to endoplasmic reticulum stress
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- positive regulation of MAP kinase activity
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
- cell adhesion
- response to xenobiotic stimulus
- response to unfolded protein
- response to mechanical stimulus
- positive regulation of smooth muscle cell proliferation
- cellular response to heat
- negative regulation of plasminogen activation
- behavioral response to pain
- positive regulation of macrophage chemotaxis
- negative regulation of endothelial cell chemotaxis
- negative regulation of cGMP-mediated signaling
- response to magnesium ion
- cellular response to tumor necrosis factor
- negative regulation of endothelial cell migration
- cell migration
- positive regulation of endothelial cell migration
- positive regulation of reactive oxygen species metabolic process
- negative regulation of nitric oxide mediated signal transduction
- positive regulation of phosphorylation
- negative regulation of blood vessel endothelial cell migration
- negative regulation of fibrinolysis
- engulfment of apoptotic cell
- positive regulation of blood vessel endothelial cell migration
- chronic inflammatory response
- negative regulation of apoptotic process
- response to calcium ion
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of endothelial cell proliferation
- negative regulation of interleukin-12 production
- positive regulation of fibroblast migration
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- platelet alpha granule
- sarcoplasmic reticulum
- secretory granule
- external side of plasma membrane
- endoplasmic reticulum
- extracellular region
- fibrinogen complex
- cell surface
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- heparin binding
- protease binding
- integrin binding
- laminin binding
- extracellular matrix structural constituent
- collagen V binding
- transforming growth factor beta binding
- phosphatidylserine binding
- fibrinogen binding
- protein binding
- endopeptidase inhibitor activity
- proteoglycan binding
- calcium ion binding
- fibronectin binding
- fibroblast growth factor binding
- low-density lipoprotein particle binding