BNIP2 Gene Summary [Human]
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | BNIP2 |
| Official Name | BCL2 interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:1083] |
| Ensembl ID | ENSG00000140299 |
| Bio databases IDs | |
| Aliases | BCL2 interacting protein 2 |
| Synonyms | 5730523P12RIK, BCL2/adenovirus E1B interacting protein 2, BCL2 interacting protein 2, BNIP2beta, NIP2, Nip21, Nip2l |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BNIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in homologues of a S
- Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
- BCH domain
- Divergent CRAL/TRIO domain
- calcium ion binding
- CRAL/TRIO domain
- GTPase activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- epithelial cancer
- prostatic carcinoma
- prostate cancer
regulates
- NFkB (complex)
- CDC42
role in cell
- differentiation
- activation in
- cell viability
- apoptosis
- cycling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- tip of protrusion
- intracellular membrane-bounded organelle
- Nucleus
- centrosome
- centriole
- cytosol
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BNIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- GTPase activator activity