ARHGAP25 Gene Summary [Human]
ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ARHGAP25 |
| Official Name | Rho GTPase activating protein 25 [Source:HGNC Symbol;Acc:HGNC:28951] |
| Ensembl ID | ENSG00000163219 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 25 |
| Synonyms | A130039I20Rik, HEL-S-308, KAIA0053, KIAA0053, RGD1562105, Rho GTPase activating protein 25 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARHGAP25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- Autophagy protein 16 (ATG16)
- PH domain
- protein binding
- Pleckstrin homology-like domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- myocardial infarction
- nicotine dependence
regulates
- RAC1
- F Actin
role in cell
- chemotaxis
- infiltration by
- organization
- cell rolling
- transendothelial migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARHGAP25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of small GTPase mediated signal transduction
- phagocytosis, engulfment
- signal transduction
- actin filament organization
Cellular Component
Where in the cell the gene product is active
- phagocytic cup
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity