PROK2 Gene Summary [Human]
This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PROK2 |
| Official Name | prokineticin 2 [Source:HGNC Symbol;Acc:HGNC:18455] |
| Ensembl ID | ENSG00000163421 |
| Bio databases IDs | |
| Aliases | prokineticin 2, protein Bv8 homolog |
| Synonyms | BV8, HH4, KAL4, MIT1, PK2, Prok1, prokineticin 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PROK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins
- G-protein-coupled receptor binding
- protein binding
- Prokineticin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hereditary disorder
- systemic lupus erythematosus
- hypogonadotropic hypogonadism 4
- heart failure
- Kallmann syndrome type 4
- primary pulmonary hypertension
role in cell
- production in
- expression in
- proliferation
- migration
- apoptosis
- phosphorylation in
- quantity
- cell viability
- chemotaxis
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PROK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- spermatogenesis
- circadian rhythm
- positive regulation of smooth muscle contraction
- elevation of cytosolic calcium ion concentration
- chemotaxis
- inflammatory response
- neuropeptide signaling pathway
- angiogenesis
- negative regulation of apoptotic process
- endothelial cell proliferation
- sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding