SMURF2 Gene Summary [Human]
Enables SMAD binding activity; identical protein binding activity; and ubiquitin-protein transferase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent SMAD protein catabolic process. Located in nuclear speck. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SMURF2 |
| Official Name | SMAD specific E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:16809] |
| Ensembl ID | ENSG00000108854 |
| Bio databases IDs | |
| Aliases | SMAD specific E3 ubiquitin protein ligase 2 |
| Synonyms | 2810411E22RIK, AI558114, RGD1310067, SMAD specific E3 ubiquitin protein ligase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SMURF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- ubiquitin protein ligase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- WW class I binding domain
- linker domain
- enzyme
- protein binding
- identical protein binding
- WW domain
- HECTc
- Domain with 2 conserved Trp (W) residues
- transforming growth factor-beta receptor binding
- ubiquitin-protein transferase activity
- WW
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Pathways
Biological processes and signaling networks where the SMURF2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- hypertension
- osteogenesis imperfecta type III
- diabetic nephropathy
- organismal death
- survival
- cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- proliferation
- function
- signaling in
- expression in
- accumulation in
- phosphorylation in
- growth
- cell viability
- apoptosis
- cell focus formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- endosomal membrane
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SMURF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of BMP signaling pathway
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of transcription, DNA-dependent
- positive regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of transforming growth factor beta receptor signaling pathway
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- nuclear speck
- membrane raft
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- protein binding
- SMAD binding