PROKR2 Gene Summary [Human]
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PROKR2 |
| Official Name | prokineticin receptor 2 [Source:HGNC Symbol;Acc:HGNC:15836] |
| Ensembl ID | ENSG00000101292 |
| Bio databases IDs | |
| Aliases | prokineticin receptor 2 |
| Synonyms | B830005M06Rik, dJ680N4.3, EG-VEGFR2, EG-VEGRF2, Gpcr73l1, GPR73b, GPR73L1, GPRg2, HH3, KAL3, PKR2, prokineticin receptor 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PROKR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Kallmann syndrome type 3
- hypogonadotropic hypogonadism 3
- cancer
- hypogonadotropic hypogonadism 3 without anosmia
- hypogonadotropic hypogonadism 7
- hypoplasia
- hereditary disorder
- hypogonadotropic hypogonadism
- hypogonadotropic hypogonadism 2 without anosmia
- Kallmann syndrome
role in cell
- growth
- activation in
- outgrowth
- surface area
- cisplatin sensitivity
- abnormal morphology
- recruitment in
- accumulation in
- release in
- permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PROKR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- circadian rhythm
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- neuropeptide Y receptor activity