Prok2 Gene Summary [Rat]
Enables G protein-coupled receptor binding activity. Predicted to be involved in several processes, including angiogenesis; endothelial cell proliferation; and positive regulation of smooth muscle contraction. Predicted to act upstream of or within circadian rhythm. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 4 with or without anosmia. Orthologous to human PROK2 (prokineticin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prok2 |
| Official Name | prokineticin 2 [Source:RGD Symbol;Acc:620280] |
| Ensembl ID | ENSRNOG00000010898 |
| Bio databases IDs | |
| Aliases | prokineticin 2 |
| Synonyms | BV8, HH4, KAL4, MIT1, PK2, Prok1, prokineticin 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prok2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Colipase and the second cysteine-rich (Cys-2) domain of Dickkopf proteins
- G-protein-coupled receptor binding
- protein binding
- Prokineticin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hereditary disorder
- systemic lupus erythematosus
- hypogonadotropic hypogonadism 4
- heart failure
- Kallmann syndrome type 4
- primary pulmonary hypertension
role in cell
- production in
- expression in
- proliferation
- migration
- apoptosis
- phosphorylation in
- quantity
- cell viability
- chemotaxis
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prok2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- spermatogenesis
- circadian rhythm
- positive regulation of smooth muscle contraction
- elevation of cytosolic calcium ion concentration
- chemotaxis
- inflammatory response
- neuropeptide signaling pathway
- angiogenesis
- negative regulation of apoptotic process
- endothelial cell proliferation
- sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding