Ptx3 Gene Summary [Mouse]
Enables (1->3)-beta-D-glucan binding activity. Acts upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Located in extracellular matrix. Is expressed in inner ear and telencephalon. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptx3 |
| Official Name | pentraxin related gene [Source:MGI Symbol;Acc:MGI:104641] |
| Ensembl ID | ENSMUSG00000027832 |
| Bio databases IDs | |
| Aliases | pentraxin related gene |
| Synonyms | LOC682447, pentraxin 3, pentraxin related gene, TNFAIP5, TSG-14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- virion binding
- Concanavalin A-like lectin/glucanases superfamily
- binding protein
- LamG
- pentraxin domain
- protein binding
- polysaccharide binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Ptx3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- neurodegeneration
- metastatic colorectal cancer
- organismal death
- diabetes mellitus
- early-onset preeclampsia
- septic shock
- streptozotocin-induced diabetes
- idiopathic pulmonary fibrosis
- bronchopulmonary aspergillosis
role in cell
- phosphorylation in
- proliferation
- apoptosis
- expression in
- growth
- migration
- synaptic transmission in
- production in
- activation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- organelle lumens
- apical cell surfaces
- membrane blebs
- extracellular matrix
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nitric oxide biosynthetic process
- inflammatory response
- negative regulation of viral entry into host cell
- response to yeast
- innate immune response
- extracellular matrix organization
- positive regulation of phagocytosis
- opsonization
- ovarian cumulus expansion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- specific granule lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- (1->3)-beta-D-glucan binding
- virion binding
- identical protein binding
- protein binding
- complement component C1q binding