PLSCR2 Gene Summary [Human]
This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PLSCR2 |
| Official Name | phospholipid scramblase 2 [Source:HGNC Symbol;Acc:HGNC:16494] |
| Ensembl ID | ENSG00000163746 |
| Bio databases IDs | |
| Aliases | phospholipid scramblase 2 |
| Synonyms | phospholipid scramblase 2, Plscr1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLSCR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- viral receptor
- nuclease
- epidermal growth factor receptor binding
- calcium ion binding
- metal ion binding
- enzyme binding
- enzyme
- protein binding
- magnesium ion binding
- SH3-domain binding
- LURP-one-related
- CD4 receptor binding
- zinc ion binding
- phospholipid scramblase
- mercury ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- nucleoli
- extracellular matrix
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLSCR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid scrambling
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- endoplasmic reticulum
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- phospholipid scramblase activity