ARFIP1 Gene Summary [Human]
Enables phosphatidylinositol-4-phosphate binding activity. Involved in negative regulation of retrograde transport, endosome to Golgi. Acts upstream of or within intracellular protein transport and regulation of protein secretion. Located in Golgi membrane; cytosol; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARFIP1 |
| Official Name | ADP ribosylation factor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:21496] |
| Ensembl ID | ENSG00000164144 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor interacting protein 1, arfaptin 1 |
| Synonyms | 2310030I10Rik, Arfaptin, arfaptin 1, ARF interacting protein 1, AW123087, D3Ertd598e, HSU52521, LOC102724121, LOC60382 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARFIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arfaptin-like domain
- protein binding
- Bin/Amphiphysin/Rvs domain
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARFIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein secretion
- intracellular protein transport
- regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- cytosol
- Golgi membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- protein domain specific binding
- protein binding
- phospholipid binding