GRPEL2 Gene Summary [Human]
Predicted to enable adenyl-nucleotide exchange factor activity and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GRPEL2 |
| Official Name | GrpE like 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:21060] |
| Ensembl ID | ENSG00000164284 |
| Bio databases IDs | |
| Aliases | GrpE like 2, mitochondrial |
| Synonyms | Afap1l1, GrpE-like 2, mitochondrial, LOC682303, Mt-GrpE#2, mt-Grpel2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRPEL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GrpE
- nucleotide exchange factor GrpE
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRPEL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into mitochondrial matrix
- intracellular protein transport
- protein folding
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane presequence translocase complex
- mitochondrion
- presequence translocase-associated import motor
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- chaperone binding
- unfolded protein binding
- adenyl-nucleotide exchange factor activity