RPS26 Gene Summary [Human]

This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. Mutations in this gene are found in Diamond-Blackfan anemia 10. There are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Aug 2017]

Details

Type
Protein Coding
Official Symbol
RPS26
Official Name
ribosomal protein S26 [Source:HGNC Symbol;Acc:HGNC:10414]
Ensembl ID
ENSG00000197728
Bio databases IDs NCBI: 6231 Ensembl: ENSG00000197728
Aliases ribosomal protein S26, 40S ribosomal protein S26
Synonyms DBA10, eS26, Ribosomal Protein S26, S26
Species
Human, Homo sapiens
OrthologiesMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPS26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • structural constituent of ribosome
  • mRNA binding
  • protein binding
  • Ribosomal protein S26e

Pathways

Biological processes and signaling networks where the RPS26 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • diamond-blackfan anemia type 10
  • metabolic syndrome X
  • Diamond-Blackfan anemia
  • psoriasis
  • dermatological disorder
  • Diamond-Blackfan anemia type 15 with mandibulofacial dysostosis
  • asthma
  • insulin-dependent diabetes mellitus
  • actinic keratosis
regulated by
regulates
  • RNR
role in cell
  • nuclear export in
  • processing in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • ribosome
  • cytosol
  • nucleoplasm
  • synapse
  • exosomes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human RPS26 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cytoplasmic translation
  • negative regulation of RNA splicing
  • translation

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • cytoplasm
  • cytosolic small ribosomal subunit
  • membrane
  • cytosol
  • small ribosomal subunit
  • synapse
  • ribosome
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding
  • structural constituent of ribosome
  • cadherin binding
  • mRNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.