HNF4G Gene Summary [Human]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | HNF4G |
| Official Name | hepatocyte nuclear factor 4 gamma [Source:HGNC Symbol;Acc:HGNC:5026] |
| Ensembl ID | ENSG00000164749 |
| Bio databases IDs | |
| Aliases | hepatocyte nuclear factor 4 gamma |
| Synonyms | hepatocyte nuclear factor 4 gamma, hepatocyte nuclear factor 4, gamma, hepatocyte nuclear factor 4 γ, hepatocyte nuclear factor 4, γ, NR2A2, NR2A3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HNF4G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- nucleic acid binding
- ligand-binding domain
- double-stranded DNA binding
- protein binding
- Ligand-binding domain of nuclear hormone receptor
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Crohn disease
- breast carcinoma
- ovarian carcinoma
- epithelial ovarian cancer
- diabetes mellitus
- uterine leiomyoma
- leiomyomatosis
- pancreatic carcinoma
- pancreatic epithelial cancer
role in cell
- apoptosis
- expression in
- proliferation
- production in
- transactivation in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytoplasmic bridges
- cytosol
- nucleoplasm
- mitotic spindle
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HNF4G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- anatomical structure development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- mitotic spindle
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity