PARVA Gene Summary [Human]
This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]
Details
| Type | Retained Intron |
| Official Symbol | PARVA |
| Official Name | parvin alpha [Source:HGNC Symbol;Acc:HGNC:14652] |
| Ensembl ID | ENSG00000197702 |
| Bio databases IDs | |
| Aliases | parvin alpha, actopaxin |
| Synonyms | 2010012A22Rik, 5430400F08Rik, Actopaxin, Actp, alpha PARVIN, CH-ILKBP, MXRA2, Parvin, Parvin alpha, parvin, alpha, Parvin α, parvin, α, α PARVIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARVA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proline-directed serine phosphorylation site
- binding protein
- protein kinase inhibitor activity
- actin binding
- paxillin-binding domain
- calponin homology (CH) domain superfamily
- protein binding
- phosphorylation site
Pathways
Biological processes and signaling networks where the PARVA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- asthma
- open-angle glaucoma
- organismal death
- congenital anomaly of cardiovascular system
- male pattern hair loss
- productive infection by HIV-1
role in cell
- adhesion
- apoptosis
- binding
- formation
- migration
- formation in
- phosphorylation in
- assembly
- cell spreading
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- caveolae-derived endocytic vesicles
- cytoskeleton
- perinuclear region
- focal complexes
- focal adhesions
- actin cytoskeleton
- Nucleus
- cytosol
- actin stress fibers
- cell-cell adherens junctions
- lamellipodia
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARVA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- outflow tract septum morphogenesis
- smooth muscle cell chemotaxis
- cilium morphogenesis
- actin-mediated cell contraction
- establishment or maintenance of cell polarity
- sprouting angiogenesis
- substrate adhesion-dependent cell spreading
- heterotypic cell-cell adhesion
- protein stabilization
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- focal adhesion
- cytoplasm
- actin cytoskeleton
- cytosol
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- cadherin binding
- protein kinase inhibitor activity