HMGN2 Gene Summary [Human]
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]
Details
| Type | Processed Transcript |
| Official Symbol | HMGN2 |
| Official Name | high mobility group nucleosomal binding domain 2 [Source:HGNC Symbol;Acc:HGNC:4986] |
| Ensembl ID | ENSG00000198830 |
| Bio databases IDs | |
| Aliases | high mobility group nucleosomal binding domain 2 |
| Synonyms | high mobility group nucleosomal binding domain 2, HMG-17 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HMGN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HMG14 and HMG17
- domain in high mobilty group proteins HMG14 and HMG 17
- transcription activation domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- mucoepidermoid carcinoma
role in cell
- expression in
- accumulation in
- replication in
- binding
- transduction
- transfection in
- internalization in
- transcription in
- recombination in
- unfolding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Extracellular Space
- chromosome
- interchromatin granules
- nucleoplasm
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HMGN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- killing of cells of other organism
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- nucleosomal DNA binding
- chromatin binding