NCOA1 Gene Summary [Human]
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | NCOA1 |
| Official Name | nuclear receptor coactivator 1 [Source:HGNC Symbol;Acc:HGNC:7668] |
| Ensembl ID | ENSG00000084676 |
| Bio databases IDs | |
| Aliases | nuclear receptor coactivator 1 |
| Synonyms | bHLHe42, bHLHe74, F-SRC-1, Gm3613, KAT13A, mNRC-1, NCOA, NRC-1, nuclear receptor coactivator 1, RIP160, SRC-1, SRC-a, STEROID receptor COACTIVATOR 1E |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCOA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase domain
- transcription regulator
- LXXLL motif
- transcription co-activator
- nuclear receptor binding domain 1
- Sumoylation motif
- retinoic acid receptor binding
- chromatin binding
- estrogen receptor binding
- Unstructured region on nuclear receptor coactivator protein
- glutamine-rich domain
- leucine-charged residue-rich domains
- nuclear receptor binding domain
- receptor binding domain
- Nuclear receptor coactivator
- Steroid receptor coactivator
- nucleic acid binding domain
- p50 binding domain
- helix-loop-helix domain
- Nuclear receptor coactivator, DUF1518
- AD2 domain
- activation domain
- histone acetyltransferase
- nuclear receptor domain
- AD1 domain
- ligand-dependent nuclear receptor interactor
- Domain of unknown function (DUF4927)
- nucleic acid binding
- GSK3 beta phosphorylation site
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- alpha helix
- protein binding
- basic helix loop helix/Per Arnt Sim domain
- activation domain AD1
- sequence-specific DNA binding
- DNA binding
- auxiliary nuclear receptor binding domain
- p300/cbp binding domain
- c-Jun binding domain
- binding protein
- PAS domain
- double-stranded DNA binding
- helix loop helix domain
- serine threonine rich domain
- retinoid X receptor binding
- ERK phosphorylation site
- CBP binding domain
Pathways
Biological processes and signaling networks where the NCOA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Androgen Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- HIF1α Signaling
- IL-12 Signaling and Production in Macrophages
- LPS/IL-1 Mediated Inhibition of RXR Function
- PPAR Signaling
- PXR/RXR Activation
- RAR Activation
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- TR/RXR Activation
- VDR/RXR Activation
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- lung carcinoma process
- epithelial cancer
- lung cancer
- hyperplasia
- liver cancer
- mixed neoplasia
- obesity
- brain cancer
- lung carcinoma
regulated by
- dexamethasone
- beta-naphthoflavone
- nifedipine
- pioglitazone
- TNF
- rifampin
- beta-estradiol
- troglitazone
- lithocholic acid
- ketoconazole
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- growth
- loss
- binding in
- cell viability
- accumulation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCOA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- positive regulation of female receptivity
- male mating behavior
- regulation of cellular response to insulin stimulus
- male gonad development
- cerebellum development
- response to progesterone stimulus
- labyrinthine layer morphogenesis
- positive regulation of neuron differentiation
- hypothalamus development
- hippocampus development
- lactation
- positive regulation of transcription from RNA polymerase II promoter by galactose
- cerebral cortex development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of thyroid hormone mediated signaling pathway
- response to retinoic acid
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- positive regulation of apoptotic process
- response to estradiol stimulus
- cellular response to hormone stimulus
- peroxisome proliferator activated receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytosol
- macromolecular complex
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity
- ligand-dependent nuclear receptor binding
- protein binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- RNA polymerase II regulatory region sequence-specific DNA binding
- protein dimerization activity
- chromatin binding
- estrogen receptor binding
- retinoid X receptor binding