ELAVL3 Gene Summary [Human]
A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ELAVL3 |
| Official Name | ELAV like RNA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:3314] |
| Ensembl ID | ENSG00000196361 |
| Bio databases IDs | |
| Aliases | ELAV like RNA binding protein 3, Hu antigen C, paraneoplastic limbic encephalitis antigen 21, paraneoplastic cerebellar degeneration-associated antigen, ELAV-like protein 3 |
| Synonyms | 2600009P04RIK, DKFZP547J036, ELAV like RNA binding protein 3, HU-antigen C, HUC, HUCL, mHuC, PLE21 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ELAVL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioblastoma
- glioblastoma cancer
- nonconvulsive seizure
- neuroendocrine prostate cancer
- epileptic seizure
role in cell
- expression in
- differentiation
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- polyribosome fractions
- Cytoplasm
- ribosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ELAVL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- cell differentiation
Molecular Function
What the gene product does at the molecular level
- protein binding
- mRNA 3'-UTR AU-rich region binding