POLR2H Gene Summary [Human]
The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | POLR2H |
| Official Name | RNA polymerase II, I and III subunit H [Source:HGNC Symbol;Acc:HGNC:9195] |
| Ensembl ID | ENSG00000163882 |
| Bio databases IDs | |
| Aliases | RNA polymerase II, I and III subunit H |
| Synonyms | LOC100912534, polymerase (RNA) II (DNA directed) polypeptide H, RGD1561203, RNA polymerase II, I and III subunit H, RPABC3, RPB17, RPB8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR2H often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA binding
- DNA-directed RNA polymerase
- enzyme
- DNA-directed RNA polymerase, subunit G
- RNA polymerase Rpb8
Pathways
Biological processes and signaling networks where the POLR2H gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- productive infection by HIV-1
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- POLR2H
role in cell
- replication in
- growth
- cell death
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR2H gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- transcription from RNA polymerase I promoter
- transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- DNA-directed RNA polymerase I complex
- protein-DNA complex
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
- DNA-directed RNA polymerase II, core complex
Molecular Function
What the gene product does at the molecular level
- RNA polymerase III activity
- RNA polymerase II activity
- RNA polymerase I activity
- single-stranded DNA binding