FBXO33 Gene Summary [Human]
This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | FBXO33 |
| Official Name | F-box protein 33 [Source:HGNC Symbol;Acc:HGNC:19833] |
| Ensembl ID | ENSG00000165355 |
| Bio databases IDs | |
| Aliases | F-box protein 33 |
| Synonyms | 5730501N20RIK, BMND12, c14 5247, F-box protein 33, Fbx33 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXO33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- F-box-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXO33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination
- protein ubiquitination
Molecular Function
What the gene product does at the molecular level
- protein binding